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Genetics Influence GLP-1 Drug Efficacy and Side Effects

4/13/2026

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Summary

Story summary

A study finds genetics influence the effectiveness and side effects of GLP-1 weight loss drugs such as Ozempic and Zepbound.
Researchers from the 23andMe Research Institute analyzed data from nearly 28,000 users.
They linked GLP1R gene variations to weight-loss outcomes and nausea risk.
Weight loss ranged from 6% to over 20%, with nausea risk from 5% to 78%.
The results support personalized weight-management approaches based on genetic differences.

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Story summary

A study finds genetics influence the effectiveness and side effects of GLP-1 weight loss drugs such as Ozempic and Zepbound.
Researchers from the 23andMe Research Institute analyzed data from nearly 28,000 users.
They linked GLP1R gene variations to weight-loss outcomes and nausea risk.
Weight loss ranged from 6% to over 20%, with nausea risk from 5% to 78%.
The results support personalized weight-management approaches based on genetic differences.