Story perspectives

3D Genome Structure Essential for Gene Regulation Revealed

4/14/2026

Summary

Story summary

Ramasamy et al. (2023) and Zhang et al. (2023) show that 3D genome organization shapes gene regulation through enhancer-promoter interactions essential for transcription.
De Laat and Duboule (2013) discuss the topology of mammalian developmental enhancers and its regulatory implications.
Furlong and Levine (2018) emphasize chromosome topology in developmental enhancers.
Murphy et al. (2024) reveal that 3D enhancer-promoter networks can predict gene expression in embryonic lineages.

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Story summary

Ramasamy et al. (2023) and Zhang et al. (2023) show that 3D genome organization shapes gene regulation through enhancer-promoter interactions essential for transcription.
De Laat and Duboule (2013) discuss the topology of mammalian developmental enhancers and its regulatory implications.
Furlong and Levine (2018) emphasize chromosome topology in developmental enhancers.
Murphy et al. (2024) reveal that 3D enhancer-promoter networks can predict gene expression in embryonic lineages.