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New CRISPR Enzyme Boosts Gene Editing Efficiency to 80%

4/15/2026

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Summary

Story summary

A team at the University of Texas at Austin, funded by the National Institutes of Health (NIH), developed Al3Cas12f.
The enzyme is smaller, addressing delivery limits of larger CRISPR proteins.
They engineered Al3Cas12f RKK, raising editing efficiency in human cells from under 10% to over 80%.
Future tests will assess performance when packaged into adeno-associated virus vectors and may advance therapies for cancer and ALS.

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Story summary

A team at the University of Texas at Austin, funded by the National Institutes of Health (NIH), developed Al3Cas12f.
The enzyme is smaller, addressing delivery limits of larger CRISPR proteins.
They engineered Al3Cas12f RKK, raising editing efficiency in human cells from under 10% to over 80%.
Future tests will assess performance when packaged into adeno-associated virus vectors and may advance therapies for cancer and ALS.