1 of 1
Story summary
- Researchers at Children's Hospital of Philadelphia (CHOP) developed STRIPE, an RNA sequencing technology to improve rare-disease diagnosis.
- STRIPE directly sequences full-length RNA to show how variants disrupt gene function.
- STRIPE has provided molecular diagnoses for patients undiagnosed by standard DNA testing.
- STRIPE has been applied to over 500 patients.
- Study was published April 15, 2026, in Science Advances, and researchers say STRIPE could bridge genetic diagnosis and RNA precision medicine.
