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Story perspectives

Asundexian Reduces Stroke Risk in Major Trial

4/17/2026

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Story summary
  • The OCEANIC-STROKE trial found that adding asundexian to antiplatelet therapy reduces ischemic stroke risk in acute noncardioembolic stroke or high-risk TIA without increasing bleeding.
  • Over two years, ischemic stroke occurred in 6.2% of asundexian patients versus 8.4% with placebo.
  • The trial enrolled 12,237 patients across 37 countries and showed consistent benefits across subgroups.
  • Experts say asundexian could transform stroke prevention, but patient selection is crucial, especially for atrial fibrillation.