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Study Finds No Benefit of Tobramycin in Bone Surgery

4/21/2026

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Story summary
  • A Journal of the American Medical Association (JAMA) study found that adding tobramycin powder to vancomycin during surgery for complex bone fractures does not significantly reduce infection rates.
  • The trial enrolled over 1,500 patients across 39 U.S. trauma centers.
  • Infection rates were 7.4% with the combination and 6.6% with vancomycin alone.
  • The data do not support adding tobramycin.