Story perspectives

Trial Boosts Liver Transplant Success, 37.5% Stop Immunosuppressants

4/22/2026

Summary

Story summary

Nature Communications reports a trial in living donor liver transplantation where donor cells were infused before surgery, enabling some recipients to withdraw from immunosuppressants.
Among 13 participants, four stopped immunosuppressants for more than three years, a 37.5% tolerance rate versus 13% historically.
Researchers say the results are preliminary and require larger trials to confirm efficacy, with the study aiming to explore new immunosuppressant medications and cells from deceased donors.

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Story summary

Nature Communications reports a trial in living donor liver transplantation where donor cells were infused before surgery, enabling some recipients to withdraw from immunosuppressants.
Among 13 participants, four stopped immunosuppressants for more than three years, a 37.5% tolerance rate versus 13% historically.
Researchers say the results are preliminary and require larger trials to confirm efficacy, with the study aiming to explore new immunosuppressant medications and cells from deceased donors.