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IVF hCG Add-On Shows No Benefit, Study Finds

4/24/2026

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Story summary
  • A University of Sydney review in Human Reproduction Update finds the intrauterine hCG add-on used in IVF does not improve pregnancy or live-birth rates.
  • The meta-analysis pooled seven randomized trials with 2,244 patients and showed no benefit across fresh or frozen transfers, embryo stages, or doses.
  • Experts note the $50-$100 add-on is listed without separate pricing and warn it exemplifies broader concerns about IVF add-ons based on weak trial data.