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High-Dose Psilocybin Cuts OCD Symptoms 73%, Remission 40%

4/25/2026

40 7 Full Breakdown

Summary

Story summary

Researchers led by Professor Francisco A. Moreno reported that high-dose psilocybin markedly reduced OCD symptoms.
The double-blind pilot enrolled fifteen adults with moderate-to-severe OCD who had failed prior treatment.
After four high doses, about 73 % achieved a >=35 % reduction, 40 % reached remission by week eight, and gains persisted at six months.
No serious adverse events occurred, with mild nausea common and blinding difficult.

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Story summary

Researchers led by Professor Francisco A. Moreno reported that high-dose psilocybin markedly reduced OCD symptoms.
The double-blind pilot enrolled fifteen adults with moderate-to-severe OCD who had failed prior treatment.
After four high doses, about 73 % achieved a >=35 % reduction, 40 % reached remission by week eight, and gains persisted at six months.
No serious adverse events occurred, with mild nausea common and blinding difficult.