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Mgm101 Ring Drives DNA Annealing, Fuels RAD52 Cancer Drug Design

4/28/2026

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Summary

Story summary

Researchers reported on April 27, 2026, in *Nucleic Acids Research* that Mgm101 forms a 19-mer ring scaffold that drives single-strand DNA annealing.
Cryo-EM captured three states—a single-strand substrate, a duplex intermediate with exposed bases, and a released double-helix product.
Bell and Wysocki say the NSF- and NIH-funded structures aid RAD52 drug design for BRCA-mutated cancers.

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Story summary

Researchers reported on April 27, 2026, in *Nucleic Acids Research* that Mgm101 forms a 19-mer ring scaffold that drives single-strand DNA annealing.
Cryo-EM captured three states—a single-strand substrate, a duplex intermediate with exposed bases, and a released double-helix product.
Bell and Wysocki say the NSF- and NIH-funded structures aid RAD52 drug design for BRCA-mutated cancers.