Story perspectives

Four Cups of Coffee Boost Gut-Brain Health, Mood

5/4/2026

Summary

Story summary

APC Microbiome Ireland at University College Cork reported that four cups of coffee improve the gut-brain axis, boosting mood and reducing stress.
Published in Nature Communications, the study found caffeinated and decaf coffee altered gut bacteria and metabolites matching the mood and stress improvements.
Lead author John Cryan, PhD, said coffee influences microbes, metabolism and well-being, linking it to lower chronic-disease risk, reduced mortality and depression rates.

1 of 1

Story summary

APC Microbiome Ireland at University College Cork reported that four cups of coffee improve the gut-brain axis, boosting mood and reducing stress.
Published in Nature Communications, the study found caffeinated and decaf coffee altered gut bacteria and metabolites matching the mood and stress improvements.
Lead author John Cryan, PhD, said coffee influences microbes, metabolism and well-being, linking it to lower chronic-disease risk, reduced mortality and depression rates.