Story perspectives

Single 25 mg Psilocybin Dose Sparks Lasting Brain Changes, Boosts Wellbeing

5/6/2026

Summary

Story summary

Researchers gave 28 healthy volunteers a single 25 mg psilocybin dose that produced lasting brain changes and improved wellbeing.
After a prior 1 mg placebo, the 25 mg dose was administered one month later, triggering a surge in brain entropy within an hour.
Diffusion tensor imaging a month after the dose showed reduced diffusion along front-to-middle brain tracts.
Participants with the largest entropy surge reported deeper insight and better wellbeing one month later.

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Story summary

Researchers gave 28 healthy volunteers a single 25 mg psilocybin dose that produced lasting brain changes and improved wellbeing.
After a prior 1 mg placebo, the 25 mg dose was administered one month later, triggering a surge in brain entropy within an hour.
Diffusion tensor imaging a month after the dose showed reduced diffusion along front-to-middle brain tracts.
Participants with the largest entropy surge reported deeper insight and better wellbeing one month later.