Full Breakdown
Kris Jenner’s Ozempic Experience – From Severe Nausea to a Peptide-Based Wellness Routine
5/8/2026, 10:01:08 PM
Ozempic Trial and Immediate Side Effects
During the May 5 2026 episode of the She MD podcast, the 70-year-old “momager” disclosed that she tried the GLP-1 medication Ozempic once, before it entered mainstream celebrity discourse. She said the injection “made me really sick,” describing nausea so intense that she told her physician, Dr. Thais Aliabadi, “I can’t work anymore. I can’t, I’m so sick. I can’t, like nauseous.” The reaction forced an immediate discontinuation of the drug.
Shift to Peptide Injections and Supplements
After the Ozempic episode, Jenner and Dr. Aliabadi “dialed around and looked at different options.” Jenner reported that a peptide injection “was really great for me” and that she now follows each injection with supplements such as fish oil and omega-3s. She characterized the new regimen as a “game changer,” noting it “bought me an extra couple hours at night” and gave her “more energy,” as well as benefits for hair, nails and skin.
Hormone Monitoring and Ongoing Wellness Practices
Jenner emphasized regular hormone testing, stating, “I get my blood drawn every three months just to keep my hormones balanced because I realized after I was 45 that was important to your physical female health—and male health, by the way.” The quarterly blood work focuses on thyroid and broader hormone panels, which she says guide her supplementation and peptide choices.
Cosmetic Surgery Context
In addition to her wellness protocol, Jenner referenced a facelift performed by Dr. Steven Levine in 2025, describing it as “very helpful.” She later refuted rumors that she disliked the procedure, calling claims that she was “furious” at her surgeon “a flat-out lie.”
Background: GLP-1 Medications and Celebrity Use
Ozempic (semaglutide) is a GLP-1 receptor agonist originally approved for type 2 diabetes and cardiovascular risk reduction. Media reports note that roughly 24 % of users experience nausea or vomiting, a side effect Jenner experienced. The drug’s off-label weight-loss popularity has prompted numerous celebrity disclosures, making Jenner’s account a notable counterpoint.
Key Figures
- Kris Jenner – Reality-TV matriarch and businesswoman, primary source of the testimony.
- Dr. Thais Aliabadi – OBGYN and co-host of She MD; provided medical guidance and approved the switch to peptides.
- Dr. Steven Levine – Plastic surgeon who performed Jenner’s 2025 facelift.
Timeline of Relevant Events
| Date | Event |
|---|---|
| ~2011 | Jenner notes she began focusing on hormone health after age 45. |
| 2025 | Undergoes facelift with Dr. Steven Levine. |
| May 5 2026 | Discusses Ozempic trial and transition to peptide injections on She MD podcast. |
| 2026 | Ongoing quarterly hormone testing and peptide-supplement regimen. |
Data & Statistics
- Ozempic side-effects: 24 % of users report nausea (source 8).
- Peptide injections: Described as short chains of amino acids that act as signaling molecules (sources 3, 12).
- Hormone testing frequency: Every three months (source 4, 16).
Why It Matters
Jenner’s candid account adds nuance to the public conversation about GLP-1 drugs. While many celebrities tout rapid weight loss, her experience highlights that severe gastrointestinal side effects can preclude continued use. Her pivot to peptide injections—an emerging but less-studied class of injectables—illustrates a broader trend of seeking alternatives perceived as “safer” or more personalized.
Official Statements & Responses
- Jenner repeatedly emphasized that Ozempic “made me really sick” and that the peptide-supplement protocol “bought me an extra couple hours at night.”
- Dr. Aliabadi responded to Jenner’s nausea by advising, “Okay, okay, let’s try something else,” and subsequently guided the peptide regimen.
- Dr. Levine confirmed performing the facelift and was defended by Jenner against unfounded rumors.
Criticism & Opposition
Medical experts caution that peptide injections are “largely untested” and not regulated by the FDA, with potential risks including stomach discomfort and pancreatitis (sources 1, 12). The broader use of GLP-1 drugs in Hollywood has also drawn criticism for promoting off-label weight-loss use without sufficient safety discussion (source 18).
Conflicting Reports & Gaps
- Some sources state the facelift occurred in 2025, while others refer to a “15-year-old” facelift, creating ambiguity about the exact timing.
- No comment was obtained from Novo Nordisk, the manufacturer of Ozempic, regarding Jenner’s experience.
Verbatim Quotes
- “We tried it once when no one knew what it was and it made me really sick.” — Kris Jenner, Momager
- “I can’t work anymore. I can’t. I’m so sick. I can’t, like nauseous.” — Kris Jenner
- “That actually bought me an extra couple hours at night.” — Kris Jenner
- “The headline right now is that I hate my facelift, and I'm really mad at — I'm furious at my doctor, Steven Levine, which couldn't be further from the truth. It's a flat-out lie. I love my facelift. I adore my doctor. I'm obsessed with him.” — Kris Jenner
- “I get my blood drawn every three months just to keep my hormones balanced because I realized after I was 45 that was important to your physical female health.” — Kris Jenner
What’s Next
Jenner indicated she will continue quarterly hormone monitoring and maintain her peptide-supplement protocol. As celebrity interest in GLP-1 alternatives grows, further medical scrutiny of peptide therapies is likely, potentially shaping future wellness recommendations for high-profile individuals.
