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UVA Finds SNOR Halts Ribosome Restart, Triggers Yeast Dormancy

5/14/2026

Summary

Story summary

University of Virginia researchers identified SNOR as essential for yeast to resume synthesis in 30 minutes of glucose readdition and showed that SNOR knockdown blocked ribosome restart, indicating a dormancy switch.
SNOR bound yeast and human ribosomes and reduced reporter synthesis, while a triple mutant (K68E, H96A, R97E) lost binding and failed to repress translation, highlighting residues.
Cryo-ET showed SNOR, eIF5A and uL1 together lock the L1 stalk and helix H69.

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Story summary

University of Virginia researchers identified SNOR as essential for yeast to resume synthesis in 30 minutes of glucose readdition and showed that SNOR knockdown blocked ribosome restart, indicating a dormancy switch.
SNOR bound yeast and human ribosomes and reduced reporter synthesis, while a triple mutant (K68E, H96A, R97E) lost binding and failed to repress translation, highlighting residues.
Cryo-ET showed SNOR, eIF5A and uL1 together lock the L1 stalk and helix H69.