Story perspectives

Western Diet Triggers MASH and Heart Failure in Mice

5/20/2026

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Summary

Story summary

Rodríguez-López, Pérez-Rodríguez and Badreddine induced MASH in PWK/PhJ mice with a Western diet, causing cardiac dysfunction.
The diet disrupted branched-chain amino-acid metabolism and increased ceramides and sphingosine-1-phosphate in liver and heart.
Metabolomic and lipidomic data linked these changes to systemic inflammation, mitochondrial stress and lower oxidative phosphorylation in cardiomyocytes.
Echocardiography showed reduced ejection fraction and impaired diastolic function, leading the authors to propose targeting amino-acid catabolism or ceramide synthesis as therapy.

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Story summary

Rodríguez-López, Pérez-Rodríguez and Badreddine induced MASH in PWK/PhJ mice with a Western diet, causing cardiac dysfunction.
The diet disrupted branched-chain amino-acid metabolism and increased ceramides and sphingosine-1-phosphate in liver and heart.
Metabolomic and lipidomic data linked these changes to systemic inflammation, mitochondrial stress and lower oxidative phosphorylation in cardiomyocytes.
Echocardiography showed reduced ejection fraction and impaired diastolic function, leading the authors to propose targeting amino-acid catabolism or ceramide synthesis as therapy.