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Single Psilocybin Dose Relieves Mouse Neuropathic Pain, Enhances Gabapentin

5/24/2026

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Summary

Story summary

University of Reading researchers found a single psilocybin dose cut neuropathic pain in mice for up to a month and boosted later gabapentin efficacy.
Pain relief began two hours after injection, lasted weeks, and gabapentin given weeks later yielded up to four days of relief, far stronger than without psilocybin.
The effect was equal in male and female mice, addressing the 30-50% of neuropathic-pain patients who lack adequate gabapentin relief.

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Story summary

University of Reading researchers found a single psilocybin dose cut neuropathic pain in mice for up to a month and boosted later gabapentin efficacy.
Pain relief began two hours after injection, lasted weeks, and gabapentin given weeks later yielded up to four days of relief, far stronger than without psilocybin.
The effect was equal in male and female mice, addressing the 30-50% of neuropathic-pain patients who lack adequate gabapentin relief.