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AI Scrapes Reddit, Finds Unexpected Side Effects of Semaglutide, Tirzepatide

5/27/2026

Summary

Story summary

University of Pennsylvania researchers used AI to scan Reddit posts for side effects of semaglutide and tirzepatide.
Analyzing 400,000 posts from 70,000 users, they found 44 % reported at least one symptom—most often gastrointestinal problems—and 4 % noted menstrual irregularities, temperature changes or fatigue, side effects rarely seen in trials.
The team said AI speeds detection, plans to study additional platforms, and disclosed a Novo Nordisk grant and Currax consulting fees.

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Story summary

University of Pennsylvania researchers used AI to scan Reddit posts for side effects of semaglutide and tirzepatide.
Analyzing 400,000 posts from 70,000 users, they found 44 % reported at least one symptom—most often gastrointestinal problems—and 4 % noted menstrual irregularities, temperature changes or fatigue, side effects rarely seen in trials.
The team said AI speeds detection, plans to study additional platforms, and disclosed a Novo Nordisk grant and Currax consulting fees.