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Story summary
- Princeton researchers used AI to map drug-induced nucleolar shape changes, publishing the findings in Cell on June 4, 2026.
- Cliff Brangwynne’s team trained a neural network on tens of thousands of nucleolar images, sorted them into four categories and identified a new “flower” shape.
- Two anti-cancer drugs induced cap-shaped nucleoli, and topotecan caused TOP1 loss and the flower morphology, linking TOP1 to nucleolar organization.
