Story perspectives

Liver CTSA Deletion Cuts LDLR, Lowers Mouse Metabolism Markers

6/25/2026

Summary

Story summary

Deleting cathepsin A (CTSA) in mouse livers lowered LDL receptor (LDLR) protein levels and reduced DiI-LDL uptake in AML12 hepatocytes.
CTSA-deficient mice showed modestly lower body weight and liver-to-body weight ratio than control mice.
Plasma glucose and triglyceride concentrations were reduced in CTSA-deficient mice relative to controls.
Primary hepatocytes from CTSA-deficient mice displayed fewer LysoTracker-positive lysosomes and lower fluorescence intensity per cell.

1 of 1

Story summary

Deleting cathepsin A (CTSA) in mouse livers lowered LDL receptor (LDLR) protein levels and reduced DiI-LDL uptake in AML12 hepatocytes.
CTSA-deficient mice showed modestly lower body weight and liver-to-body weight ratio than control mice.
Plasma glucose and triglyceride concentrations were reduced in CTSA-deficient mice relative to controls.
Primary hepatocytes from CTSA-deficient mice displayed fewer LysoTracker-positive lysosomes and lower fluorescence intensity per cell.