Story perspectives

Family Study Finds CGAS Variant Extends Healthspan, Delays Disease

6/26/2026

Summary

Story summary

Researchers at Leiden University Medical Center presented that family studies identify genetic variants linked to longer healthspan.
The Leiden Longevity Study of 212 sibships found four genome regions and 12 variants, including a CGAS variant that may lower inflammation.
Long-lived parents' offspring develop cardiometabolic disease 13 years later.
Scientists will add the CGAS mutation to killifish at the Max Planck Institute for Biology of Ageing to test lifespan effects.

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Story summary

Researchers at Leiden University Medical Center presented that family studies identify genetic variants linked to longer healthspan.
The Leiden Longevity Study of 212 sibships found four genome regions and 12 variants, including a CGAS variant that may lower inflammation.
Long-lived parents' offspring develop cardiometabolic disease 13 years later.
Scientists will add the CGAS mutation to killifish at the Max Planck Institute for Biology of Ageing to test lifespan effects.