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Story summary
- University of Southern California researchers engineered granulocyte-monocyte progenitor (GMP) cells to self-renew and continuously produce macrophages in mice.
- Biologist Qi-Long Ying reported a chemical cocktail that enables GMP proliferation and cryopreservation.
- Injected engineered GMPs spread throughout mice with blood and solid tumors, where their progeny slowed tumor growth versus direct macrophage injections.
- Published in Cell in 2026, the work suggests targeting immune-cell progenitors may boost CAR-M immunotherapies.
