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King's KCL-286 Repairs DNA, Lowers Alzheimer’s Inflammation

7/14/2026

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Summary

Story summary

Researchers at King's College London showed that oral KCL-286 repaired DNA and reduced brain inflammation in Alzheimer’s mice.
The compound, originally created for spinal-cord injury, activates retinoic acid receptor beta and has passed a Phase 1 safety trial in healthy volunteers.
Corcoran’s team will treat about 20 patients and monitor blood DNA-repair signals.
If funding is secured, the study could confirm efficacy within a year.

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Story summary

Researchers at King's College London showed that oral KCL-286 repaired DNA and reduced brain inflammation in Alzheimer’s mice.
The compound, originally created for spinal-cord injury, activates retinoic acid receptor beta and has passed a Phase 1 safety trial in healthy volunteers.
Corcoran’s team will treat about 20 patients and monitor blood DNA-repair signals.
If funding is secured, the study could confirm efficacy within a year.