Story perspectives

OSU Nanoparticles Slash Brain Tumor Burden, Boost Survival

7/16/2026

Summary

Story summary

Oregon State University researchers gave mice with glioblastoma mannose-cholesterol lipid nanoparticles.
The sugar coating enabled the particles to cross the blood-brain barrier 9.9 times better than uncoated particles.
Tumor burden fell from 52 % to 2.3 % of the brain after 28 days while median survival rose from 33 to 49 days.
The results were published in the 2026 Journal of Controlled Release and suggest a platform for brain-targeted mRNA therapies.

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Story summary

Oregon State University researchers gave mice with glioblastoma mannose-cholesterol lipid nanoparticles.
The sugar coating enabled the particles to cross the blood-brain barrier 9.9 times better than uncoated particles.
Tumor burden fell from 52 % to 2.3 % of the brain after 28 days while median survival rose from 33 to 49 days.
The results were published in the 2026 Journal of Controlled Release and suggest a platform for brain-targeted mRNA therapies.