Story perspectives

Blocking EP2 Revives Immune Cleanup, Reverses Mouse Aging

7/18/2026

Summary

Story summary

Researchers led by Jessy Tan Yuting lowered EP2 in mouse macrophages, restoring neutrophil cleanup.
The intervention reversed aging signs in the mice.
Both genetic EP2 deletion and EP2-blocking drugs improved heart health, reduced fat, and lowered chronic inflammation in older mice.
Liver and heart samples showed tissues contain more EP2 in macrophages and fewer macrophage-neutrophil contacts, prompting the authors to propose aging may stem from a failing immune-cell cleanup system.

1 of 1

Story summary

Researchers led by Jessy Tan Yuting lowered EP2 in mouse macrophages, restoring neutrophil cleanup.
The intervention reversed aging signs in the mice.
Both genetic EP2 deletion and EP2-blocking drugs improved heart health, reduced fat, and lowered chronic inflammation in older mice.
Liver and heart samples showed tissues contain more EP2 in macrophages and fewer macrophage-neutrophil contacts, prompting the authors to propose aging may stem from a failing immune-cell cleanup system.