Story perspectives

First patient receives experimental ZI-MA4-1 cancer therapy in Manchester

7/31/2026

Summary

Story summary

Tracy Tomlinson, 58, became the first patient worldwide to receive the experimental cancer therapy ZI-MA4-1.
She was treated at The Christie hospital in Manchester in a trial that also involves the Royal Marsden in London.
ZI-MA4-1 combines her natural-killer cells with engineered T-cell receptors targeting the Mage-A4 protein, an off-the-shelf donor-cell product that can yield hundreds of doses per batch, potentially speeding delivery and lowering costs.

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Story summary

Tracy Tomlinson, 58, became the first patient worldwide to receive the experimental cancer therapy ZI-MA4-1.
She was treated at The Christie hospital in Manchester in a trial that also involves the Royal Marsden in London.
ZI-MA4-1 combines her natural-killer cells with engineered T-cell receptors targeting the Mage-A4 protein, an off-the-shelf donor-cell product that can yield hundreds of doses per batch, potentially speeding delivery and lowering costs.