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Plasma p-tau217 Predicts 78% Ten-Year Cognitive Impairment Risk

8/17/2026

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Summary

Researchers Flag p-tau217

Researchers in the United Kingdom reported that plasma p-tau217 levels indicate a 78% ten-year risk of cognitive impairment.
A JAMA analysis of 2,700 adults average age 70 found p-tau217 predicts a 15% five-year and 45% ten-year risk.
Reisa Sperling, M.D., warned that p-tau217 alone cannot fully predict risk because age, genetics and other factors influence levels.

Summary

Estrogen Lowers Dementia

Estrogen-only hormone therapy was linked to 35% lower odds of Alzheimer’s pathology and 39% lower odds of dementia in a study of 21,000 women.
Among 258 users and 2,701 non-users, 18% of users showed no Alzheimer’s signs versus 10% of non-users.
The study, which excluded combined estrogen-progestin therapy and mainly involved hysterectomy patients, cannot establish causality and urges placebo-controlled trials of timing and duration.

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Researchers Flag p-tau217

Researchers in the United Kingdom reported that plasma p-tau217 levels indicate a 78% ten-year risk of cognitive impairment.
A JAMA analysis of 2,700 adults average age 70 found p-tau217 predicts a 15% five-year and 45% ten-year risk.
Reisa Sperling, M.D., warned that p-tau217 alone cannot fully predict risk because age, genetics and other factors influence levels.

1 / 2