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Choline Restores Mitochondrial Aging in Worms, Study Finds

8/17/2026

Summary

Story summary

Researchers led by Maria Ermolaeva (Leibniz Institute on Aging) showed that feeding choline or phosphatidylcholine reverses mitochondrial aging in roundworms and may do so in humans.
The study linked worm experiments to human data, showing aging proceeds through stress resistance, metabolic change, then epigenetic change.
Researchers observed sex-specific differences and a decline in human phosphatidylcholine levels around menopause.
They suggest that targeting phosphatidylcholine could modify mitochondrial and systemic aging.

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Story summary

Researchers led by Maria Ermolaeva (Leibniz Institute on Aging) showed that feeding choline or phosphatidylcholine reverses mitochondrial aging in roundworms and may do so in humans.
The study linked worm experiments to human data, showing aging proceeds through stress resistance, metabolic change, then epigenetic change.
Researchers observed sex-specific differences and a decline in human phosphatidylcholine levels around menopause.
They suggest that targeting phosphatidylcholine could modify mitochondrial and systemic aging.