Story perspectives

CD4 cytotoxic T cells expand in Japanese supercentenarians

8/19/2026

Summary

Story summary

Researchers led by immunologist Kosuke Hashimoto of Osaka University reported CD4 cytotoxic T cells expand in supercentenarians.
The study of blood from 28 Japanese participants, including 10 centenarians, found median CD4 CTL levels rose from 4 % in people in their 70s-90s to 9.6 % in centenarians, 17.6 % in supercentenarians.
One participant under 100 showed highest CD4 CTL proportion without exhaustion, with about 33 % of those cells cloned from a single cell.

1 of 1

Story summary

Researchers led by immunologist Kosuke Hashimoto of Osaka University reported CD4 cytotoxic T cells expand in supercentenarians.
The study of blood from 28 Japanese participants, including 10 centenarians, found median CD4 CTL levels rose from 4 % in people in their 70s-90s to 9.6 % in centenarians, 17.6 % in supercentenarians.
One participant under 100 showed highest CD4 CTL proportion without exhaustion, with about 33 % of those cells cloned from a single cell.