Story perspectives

TOFA boosts fat burning and improves metabolism in mice

8/23/2026

Summary

Story summary

UC Berkeley researchers reported that TOFA reduces fat and improves metabolic health in mice.
TOFA blocks lipid synthesis, activates PPAR?/? and raises cellular fat burning up to 18%.
In mice, TOFA lowered triglycerides and prevented the rise seen with other ACC inhibitors.
Combining TOFA with GLP-1 drugs semaglutide or tirzepatide improved weight, glucose, insulin and triglycerides versus each alone.
Researchers founded ReRx Therapeutics to pursue human trials of TOFA.

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Story summary

UC Berkeley researchers reported that TOFA reduces fat and improves metabolic health in mice.
TOFA blocks lipid synthesis, activates PPAR?/? and raises cellular fat burning up to 18%.
In mice, TOFA lowered triglycerides and prevented the rise seen with other ACC inhibitors.
Combining TOFA with GLP-1 drugs semaglutide or tirzepatide improved weight, glucose, insulin and triglycerides versus each alone.
Researchers founded ReRx Therapeutics to pursue human trials of TOFA.