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Story summary
- University of South Carolina scientists injected Nano-ERASER nanogel to degrade PTBP1 in astrocytes.
- PTBP1 degradation caused astrocytes to convert into functional neurons in brain organoids and mice.
- Treated mice built nests and solved water mazes more efficiently after two injections.
- Treated mice showed higher neuron density, reduced inflammation, and fewer protein-aggregate markers.
- Microelectrode recordings verified that new neurons formed active networks comparable to native cells.
