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Upadacitinib Regrows Hair in Severe Alopecia Areata Trials

9/6/2026

Summary

Story summary

International researchers report upadacitinib significantly regrows hair in severe alopecia areata patients.
Two Phase 3 trials enrolled 1,399 participants and lasted 24 weeks, leaving longer-term effects unknown.
Daily 15 mg or 30 mg upadacitinib achieved SALT <= 20 in 45-55 % versus 1-4 % placebo.
Up to 22.5 % of treated participants regrew all scalp hair, compared with 4 % on placebo.
Serious adverse events were rare and quality-of-life scores improved among upadacitinib users.

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Story summary

International researchers report upadacitinib significantly regrows hair in severe alopecia areata patients.
Two Phase 3 trials enrolled 1,399 participants and lasted 24 weeks, leaving longer-term effects unknown.
Daily 15 mg or 30 mg upadacitinib achieved SALT <= 20 in 45-55 % versus 1-4 % placebo.
Up to 22.5 % of treated participants regrew all scalp hair, compared with 4 % on placebo.
Serious adverse events were rare and quality-of-life scores improved among upadacitinib users.