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25,000-Year-Old Betel Nut Use Shows Earliest Arecoline Evidence

9/10/2026

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Story summary
  • Australian researchers led by Prof Adam Brumm identified 25,000-year-old betel-nut use in Indonesia.
  • Two Sulawesi skeletons showed deep, rounded tooth grooves that sometimes exposed the dental pulp.
  • The grooves indicate the individuals habitually sucked hard, abrasive betel nuts.
  • Chemical analysis detected traces of the psychoactive compound arecoline in the teeth.
  • Dr Elisa Guerra-Doce called the findings the earliest direct evidence of human psychoactive plant use.