49ers Face Injury Crunch Ahead of Week 4 Broncos Clash

Nearly four weeks into the NFL season, the San Francisco 49ers entered Week 4 with ten players on the Wednesday injury report, including marquee names wide receiver Mike Evans, defensive end Nick Bosa and left tackle Trent Williams. General manager John Lynch discussed each player’s condition on KNBR, indicating that the team hopes to keep the absences short while remaining competitive.

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• Mike Evans (WR, Tampa Bay Buccaneers) – Carted off after a rib injury in the 36-30 win over the Arizona Cardinals.

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• Nick Bosa (DE, 49ers) – Suffered a calf strain in practice the previous week. The team did not place him on injured reserve due to limited spots. Lynch described Bosa’s rehab as diligent but deemed his return “unlikely” for Week 4, projecting a few-week absence.

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• Trent Williams (LT, 49ers) – Left the Cardinals game early with a stinger and subsequently rested his neck. He missed Wednesday’s practice but could return for Thursday’s session, making his participation in Week 4 “likely,” according to Lynch.

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He noted that calf injuries can be “murky” and that the team will reassess Bosa’s status after the next week’s practice. Regarding Williams, Lynch indicated that the left tackle’s neck issue was being monitored but did not expect it to sideline him for the Broncos matchup.

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• “He is old school in his mindset. He doesn’t want to miss,” — John Lynch, francisco general manager

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The injuries force the 49ers to adjust their offensive and defensive lineups, testing depth at critical positions. While the loss of Evans and Bosa could strain the passing attack and pass rush, the potential return of Williams offers some stability on the offensive line. Lynch’s optimistic tone suggests the team believes the setbacks will be brief, a factor that could influence their pursuit of an undefeated start.

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