Back to today’s briefing

Story perspectives

Lithocholic Acid Boosts Longevity and Metabolic Health

1/10/2025

32 4

Summary

Story summary

Researchers have unveiled that lithocholic acid (LCA), a bile acid, can replicate the benefits of caloric restriction by activating AMPK, leading to improved health and longevity in model organisms. In older mice, LCA boosted physical performance and metabolic health while preserving muscle mass, hinting at its potential as a caloric restriction mimetic and its connection to gut microbiota changes.

1 of 1

Story summary

Researchers have unveiled that lithocholic acid (LCA), a bile acid, can replicate the benefits of caloric restriction by activating AMPK, leading to improved health and longevity in model organisms. In older mice, LCA boosted physical performance and metabolic health while preserving muscle mass, hinting at its potential as a caloric restriction mimetic and its connection to gut microbiota changes.