Back to today’s briefing

Story perspectives

Reactivating Maternal X Chromosome Boosts Memory in Aging Mice

1/23/2025

47 6

Summary

Story summary

Female mice with only a maternal X chromosome show signs of accelerated brain aging and cognitive decline, according to UCSF research. Reactivating dormant genes on the maternal X led to improved memory in older mice, offering hope for understanding sex differences in cognitive decline and potential strategies for combating diseases like Alzheimer’s.

1 of 1

Story summary

Female mice with only a maternal X chromosome show signs of accelerated brain aging and cognitive decline, according to UCSF research. Reactivating dormant genes on the maternal X led to improved memory in older mice, offering hope for understanding sex differences in cognitive decline and potential strategies for combating diseases like Alzheimer’s.