Great Things’ Rapid-Return Investment Model Coupled with a 20% Philanthropy Mandate

Through his family office Great Things, entrepreneur Giorgos Tseti s, co-founder of Nutrafol, channels venture-capital-style profits into charitable giving. The firm commits at least 20 % of annual net realized profits to nonprofits and makes three- to five-year pledges that span causes from a Bronx after-school boxing academy to Every Cure, which repurposes existing drugs for rare diseases.

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Tsetis launched Great Things roughly a year after selling his remaining stake in Nutrafol to Unilever at a $3.5 billion valuation. The office’s decision-making is concentrated in Tsetis and partner Roman Kalantari, a former Nutrafol chief experience and technology officer. Their donor-advised fund acts as a buffer when investment returns fall short of charitable commitments, mirroring the profit-sharing mechanisms of venture capital and private-equity funds.

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In the past 18 months, Great Things has invested nearly $40 million in high-growth startups and allocated about $7 million to nonprofit gifts and pledges, according to Tsetis. A secondary exit from AI firm Anthropic generated a seven-times return within that period. Looking ahead, Tsetis projects an additional $60 million of deployments over the next two years. While the AI boom accelerated early gains, the firm is now tempering its enthusiasm, shifting focus to late-stage rounds to prioritize liquidity.

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• “I've got kids, and obviously I think about the future. But what I think more about is we need to solve problems together as we speak,” — Giorgos Tsetis

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• “Basically what he's done is just turned the profit-sharing interest into a charitable-sharing interest,” — Gabriel Cooperman, Tsetis' financial advisor and a managing director at UBS Wealth Management

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