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Methylphenidate Cuts 23% Higher Pupil Variability in ADHD

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Story summary
  • Researchers at India's Indraprastha Institute of Technology Delhi analyzed eye-tracking data from 50 Chilean children (28 ADHD, 22 controls) aged 10-12.
  • Unmedicated ADHD participants showed about 23% higher trial-to-trial pupil variability than controls.
  • When given methylphenidate, 17 ADHD children displayed reduced variability and stronger pupil responses.
  • Researchers warned the medication effect may reflect pharmacology rather than normalized attention, noting the findings in Scientific Reports 2026.